The prevalence of obesity and overweight has continued to increase at an alarming rate over the last several decades, becoming a major public health issue around the world. The fifth leading cause of global deaths, obesity increases the risk of numerous chronic diseases, including type 2 diabetes, cardiovascular disease, certain cancers and musculoskeletal disorders.

Given the widespread impact of the global obesity epidemic – and the undesirable side effects linked with numerous anti-obesity medications –  the scientific community is delving into the potential of botanical remedies to combat overweight and obesity for their safety and effectiveness. 

Among these botanicals is forskolin, an extract derived from the roots of Coleus forskohlii, a plant member of the mint family. Forskolin has been shown to activate an enzyme called hormone-sensitive lipase (HSL), which plays a role in breaking down fats stored in fat cells. This can lead to increased fat metabolism and potentially aid in weight loss. 

A recent study, published in the International Journal of Pharmacology, investigated the anti-obesity properties of Forcslim™, a patented extract derived from C. forskohlii containing 10% forskolin, using both laboratory and animal models.

In the in vivo study, researchers utilized cultured cells to assess Forcslim’s impact on fat cells and their metabolism. They observed that the extract reduced the formation of new fat cells. Additionally, they noted that higher concentrations of the extract inhibited the activity of a fat-digesting enzyme, thereby preventing excessive fat accumulation in the cells by impeding fat digestion, suggesting potential benefits in combating obesity.

Next, the team of researchers investigated the potential anti-obesity effects of Forcslim using a mouse model. The study involved two groups of mice: one group was fed a normal diet, while the other was fed a high-calorie cafeteria diet, both for a duration of 40 days. The researchers evaluated various aspects related to obesity, including appetite suppression, nutrient absorption, heat production (thermogenesis), and the formation of fat cells (adipogenesis).

The results of the study showed that administering Forcslim to mice on a cafeteria diet resulted in positive outcomes, including reduced obesity-related biochemical markers like blood sugar levels and lipid profiles. It also led to decreased liver and small intestine weight, indicating potential organ health improvements.

In summary, the findings strongly indicate that C. forskohlii holds promise as a natural source of medicinal ingredients for combating obesity and metabolic diseases in humans. This study underscores the importance of future investigations into Forcslim as a sustainable option for addressing these health concerns.